Table 4.

Respective values of miR-193a, WT1, PODXL, proteinuria, GFR, and Scr for appraising renal survival of IMN patients.

Biomarkers	IMN patients	Value	Sensitivity	Specificity	AUC	95%CI
miR-193a	Stage I	1.05	0.357	0.908	0.696	0.603–0.790
	Stage II	5.29	0.620	0.775	0.747	0.661–0.832
	Stage III + IV	6.22	0.788	0.667	0.788	0.686–0.891
	All*	5.77	0.544	0.866	0.753	0.701–0.805
WT1	Stage I	5.54	0.357	0.942	0.646	0.542–0.750
	Stage II	1.00	0.560	0.825	0.696	0.603–0.790
	Stage III + IV	0.91	0.788	0.667	0.754	0.643–0.866
	All*	1.00	0.552	0.841	0.717	0.660–0.775
PODXL	Stage I	3.46	0.857	0.392	0.650	0.557–0.743
	Stage II	4.67	0.880	0.512	0.743	0.660–0.827
	Stage III + IV	7.07	0.424	0.949	0.734	0.618–0.850
	All*	4.81	0.744	0.582	0.723	0.669–0.777
Proteinuria	Stage I	3.36	0.405	0.833	0.634	0.534–0.734
	Stage II	3.45	0.940	0.487	0.725	0.640–0.811
	Stage III + IV	4.85	0.818	0.538	0.732	0.617–0.846
	All*	3.50	0.728	0.640	0.718	0.663–0.773
GFR	Stage I	82.85	0.786	0.533	0.687	0.602–0.772
	Stage II	60.90	0.560	0.787	0.997	0.606–0.789
	Stage III + IV	48.52	0.788	0.590	0.714	0.594–0.834
	All*	67.70	0.680	0.615	0.690	0.635–0.745
Scr	Stage I	85.65	0.857	0.408	0.657	0.560–0.754
	Stage II	142.26	0.960	0.337	0.684	0.592–0.776
	Stage III + IV	419.47	0.424	0.974	0.671	0.540–0.801
	All*	142.26	0.648	0.615	0.656	0.598–0.714

IMN: Idiopathic membranous nephropathy; GFR: glomerular filtration rate; Scr: serum creatinine; AUC: area under the curve; CI: confidence interval

*With the whole IMN patients considered, including those at stages I, II, and III + IV.