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. 2019 Jul 25;46:193–201. doi: 10.1016/j.ebiom.2019.07.041

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© 2019 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — AZM and MIN show reciprocal media-dependent inhibitory activities vs. MDR A baumannii and synergize strongly when combined. AZM and MIN activities were assessed in the standard bacteriological medium CA-MHB (A-C), in the physiologically relevant amended tissue culture medium RPMI+ (D-F), and in the presence of 20% fresh human whole blood (G-I). (A) Bactericidal activity of AZM in CA-MHB. (B) Bactericidal activity of MIN in CA-MHB. (C) Fractional inhibition concentration (FIC) plot for AZM and MIN combinations in CA-MHB. (D) Bactericidal activity of AZM in RPMI+. (E) Bactericidal activity of MIN in RPMI+. (F) FIC plot for AZM and MIN combinations in RPMI+. (G) Bactericidal activity of AZM in 20% fresh human whole blood/ 80% RPMI. (H) Bactericidal activity of MIN in 20% fresh human whole blood/ 80% RPMI. (I) Fractional bactericidal concentration (FBC) plot for AZM and MIN combinations in 20% fresh human whole blood/ 80% RPMI. All experiments were conducted in triplicate. A representative plot is shown for each of the fractional inhibition/bactericidal graphs. Synergy is indicated by an FICI or FBCI of ≤0.5.