Fig. 3.

Therapeutic benefit of AZM and MIN combinations in a murine model of A. baumannii pneumonia. C57BL/6J mice were infected intratracheally with 1 × 10⁸ MDR A. baumannii strain AB5075. AZM and MIN were administered subcutaneously and intraperitoneal respectfully, both 1 and 24 h post infection at the indicated dosages. (A) Lungs were harvested 30 h post infection, homogenized, and plated for CFU enumeration. N = 7 for the no drug controls and n = 8 for each treatment condition. (B) and (C) Mouse survival was monitored for 6 days with n = 5 animals per group. For panels (A), statistical significance was calculated using a two-way ANOVA with ** ≤0.01 and *** ≤0.001, interactions are considered non-significant unless otherwise noted.