Fig. 6.

AZM and MIN synergy against additional high-priority MDR pathogens. AZM and MIN synergy experiments were conducted against other important MDR human pathogens utilizing checkerboard assays. All data are presented as fractional inhibition concentration plots where the MIC of each drug in monotherapy is set to 1.0. (A) MDR K. pneumoniae strain K1100 in CA-MHB. (B) MDR P. aeruginosa strain P4 in CA-MHB. (C) MDR S. aureus strain TCH1516 in CA-MHB. (D) MDR K. pneumoniae strain K1100 in RPMI+. (E) MDR P. aeruginosa strain P4 in RPMI+. (F) MDR S. aureus strain TCH1516 in RPMI+. A representative plot is shown for each experiment that was conducted in triplicate. The FICI is indicated on the graph with an FICI of ≤0.5 indicating synergistic interactions.