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. 2019 Jul 31;8(1):1146–1156. doi: 10.1080/22221751.2019.1648184

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Female mice implanted with estradiol pellets were protected from H5N1 infection. Non-pregnant female Balb/c mice implanted with estradiol or placebo pellets were infected with H5N1 as described above. (A) Serum estradiol levels (n = 9–17 mice/group/time point); (B) Body Weight (BW) (n = 17 mice/group) and (C) pulmonary viral load (n = 7 mice/group/time point). Data are expressed as mean ± SEM. Serum estradiol levels and BW were analyzed by two-way ANOVA. Pulmonary viral titers were analyzed by Mann–Whitney test after log transformation. ***p < 0.001. Data are representative of 2–3 independent experiments with similar results.