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. 2019 Jul 24;8(1):1066–1075. doi: 10.1080/22221751.2019.1643260

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Dynamic seroconversion of anti-HEV, HEV RNA, ALT, AST, histopathology and immunofluorescence of newborn rabbits. and (B) Dynamic seroconversion of antiHEV, HEV RNA, ALT and AST of group A newborn rabbits Aa and Ab with fecal HEV RNA shedding. (C) Dynamic seroconversion of anti-HEV of group A newborn rabbits Ac with anti-HEV antibodies. (D) Liver histopathology and Immunofluorescence staining of HEV ORF2 and ORF3 in liver of newborn rabbits. (a, d) Liver section of group A newborn dead rabbit and group D newborn rabbit showed no visible pathological signs of HEV infection; (b, c) various pathological changes in liver sections of group A newborn rabbits Aa and Ab respectively; (e, i, h, l) negative signals for HEV ORF2 and ORF3 antigen in liver of group A newborn dead rabbit and group D newborn rabbit; (f, g, j, k) positive signals for HEV ORF2 and ORF3 antigen in livers from group A newborn rabbits Aa and Ab. Original magnification,×200.