Table 4. Protection of rabbits against challenge with rHEV-3.

Groups (No.)	HEV 239 (μg)	Pre-challenge	Post challenge
		Mean anti-HEV level ± SD(U/mL)	Number of rabbits shedding virus in fecesa	Ab resp.b	Number of rabbits with adverse pregnancy outcomesc	P valuesf
E (6)	2×10	389.2 ± 112.3	0/6	−	0/6	0.002*
F (6)	2×5	339.5 ± 165.2	0/6	−	1/6d	0.015*
G (6)	2×0	<1	6/6	+ (>4fold)	6/6e	−

^aNumber of rabbits shedding virus in feces/total number of rabbits in the group.

^bAb resp. (+) represents the mean anti-HEV level in every group post challenge is four times higher than that pre-challenge.

^cNumber of rabbits with adverse pregnancy outcomes/total number of rabbits in the group.

^dOne rabbit had stillbirth.

^eOne rabbit died, three rabbits had stillbirth and two rabbits had miscarriage.

^fThe vaccine efficacy compared to group G.

*Significantly different, P < 0.05.