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. Author manuscript; available in PMC: 2019 Aug 27.
Published in final edited form as: Cell Rep. 2019 Aug 13;28(7):1845–1859.e5. doi: 10.1016/j.celrep.2019.07.031

Figure 2. Loss of Drp1 Decreases KRas-Driven Glycolytic Flux.

Figure 2.

(A) Soft agar growth from Figure 1E to analyze media color.

(B) ECAR of indicated MEFs during a glycolysis stress test (GST). Glucose, oligomycin, and 2-deoxyglucose (2-DG) were added at the indicated time points (representative result, n = 3).

(C) Extracellular lactate of indicated MEFs (n = 3).

(D) Radiotracer flux of 3H-glucose to 3H2O in indicated MEFs (n = 3).

(E) Calculated ECAR attributable to glycolysis of the indicated 14-day doxycycline-treated PDAC cell lines (n = 4).

(F) Radiotracer flux of 3H-glucose to 3H2O of the indicated 14-day doxycycline-treated PDAC cell lines (n = 3).