Table 1. Definitions for the classification of evidence for fungal infections*.

Term	Definition†
Persistent necrosis‡	Presence of necrosis after >2 surgical debridements
Persistent laboratory evidence of fungal infection‡	Presence of positive histopathology and/or culture after >2 surgical debridements
Wounds meeting criteria for IFI	Includes wounds with persistent necrosis and persistent laboratory evidence of fungal infection
Wounds highly suspicious for fungal infection (high-suspicion wounds)	Includes wounds that did not meet the criteria for an IFI but produced signs and symptoms suggestive of a deep SSTI ascribed to a fungus (based on the use of antifungals for >10 d and a physician report). Wounds that did not meet criteria for an IFI but required a proximal amputation were included, irrespective of the duration of antifungal use.
Wounds with low suspicion for fungal Infection (low-suspicion wounds)	Includes wounds that did not meet the criteria for an IFI and did not meet the criteria for a deep SSTI. This category also includes wounds that produced signs and symptoms of a deep SSTI attributed to bacteria (based on physician report or the use of antifungals for <10 d) but with laboratory evidence of fungus (i.e., positive fungal cultures, histopathologic findings, or both).

*IFI, invasive fungal infection; SSTI, skin and soft tissue infection.
†Centers for Disease Control and Prevention National Healthcare Safety Network criteria for deep SSTIs were adapted for this definition (19).
‡Excludes any additional debridement that was performed in the battlefield hospitals in Afghanistan.