Table 3. Odds ratios of infection occurrence, nested case–control analysis in study of Clostridiodes difficile infection in older adults with cancer.
| Characteristic |
Primary analysis: cancer patients and non–cancer patients* |
|||
|---|---|---|---|---|
| Unadjusted OR (95% CI) |
p value |
Adjusted OR (95% CI)† |
p value |
|
| Tumor type | ||||
| None | 1.00 | 1.00 | ||
| Solid | 1.13 (1.03–1.24) | 0.01 | 1.05 (0.95–1.16) | 0.32 |
| Liquid | 1.94 (1.67–2.26) | <0.001 | 1.74 (1.48–2.06) | <0.001 |
| Prior hospitalizations | ||||
|---|---|---|---|---|
| 0 | 1.00 | 1.00 | ||
| 1 | 1.11 (0.96–1.28) | 0.15 | 1.07 (0.93–1.23) | 0.37 |
| 2 | 2.33 (2.02–2.69) | <0.001 | 1.83 (1.56–2.14) | <0.001 |
| 3 | 3.55 (2.99–4.20) | <0.001 | 2.68 (2.22–3.23) | <0.001 |
| 4 | 4.93 (4.09–5.96) | <0.001 | 3.49 (2.81–4.31) | <0.001 |
| >5 | 8.63 (7.39–10.09) | <0.001 | 5.76 (4.74–6.99) | <0.001 |
| Prior skilled nursing facility stay | ||||
|---|---|---|---|---|
| No | 1.00 | 1.00 | ||
| Yes | 3.93 (3.56–4.33) | <0.001 | 1.59 (1.39–1.82) | <0.001 |
*For cancer patients, diagnosis was made during 2006–2010. OR, odds ratio. †Adjusted odds of C. difficile infection based on conditional logistic regression model. Adjusted for age, sex, race, geographic region, urban/rural location, prior hospitalizations, and prior skilled nursing facility stays. Separate models were conducted for all patients with a cancer diagnosed 2006–2010 and noncancer patients, and for recently diagnosed cancer patients (diagnosis 2009–2010) and non–cancer patients.