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. 2019 Aug 26;374(1783):20190070. doi: 10.1098/rstb.2019.0070

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© 2019 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 5. — A generalized scheme shows in holometabolous insects how stage specification genes relate to each other, to the hormonal environment that orchestrates metamorphosis and to the cellular responses of the imaginal primordium and the general epidermis. Symbols that are greyed out are either absent or suppressed. See text for details. 20E, 20-hydroxyecdysone; Br, Broad; E93, Ecdysone-inducible protein 93F; JH, juvenile hormone; Kr-h1, Krüppel-homolog 1; MIF, metamorphosis initiation factor. Based on [24,57,59,61,63,65,66,69,70]. (Online version in colour.)