Table 1.
route | dose | hamsters |
rats |
||||
---|---|---|---|---|---|---|---|
n | lethality | % | n | colonization | % | ||
intact skin | 104 | 4 | 0 | 0.0 | |||
106 | 8 | 0 | 0.0 | ||||
107 | 4 | 0 | 0.0 | ||||
108 | 8 | 2 | 25.0 | ||||
shaved skin | 104 | 4 | 0 | 0.0 | |||
106 | 8 | 2 | 25.0 | ||||
107 | 4 | 3 | 75.0 | ||||
108 | 8 | 5 | 62.5 | ||||
abraded skin | 101 | 12 | 5 | 41.7 | 3 | 0 | 0.0 |
102 | 12 | 8 | 66.7 | 5 | 0 | 0.0 | |
103 | 12 | 10 | 83.3 | 2 | 2 | 100.0 | |
104 | 6 | 6 | 100.0 | ||||
106 | 3 | 3 | 100.0 | ||||
108 | 4 | 4 | 100.0 | ||||
conjunctiva | 102 | 4 | 0 | 0.0 | |||
103 | 4 | 0 | 0.0 | ||||
104 | 8 | 0 | 0.0 | ||||
105 | 12 | 0 | 0.0 | ||||
106 | 24 | 9 | 37.5 | ||||
107 | 20 | 14 | 70.0 | ||||
108 | 36 | 36 | 100.0 | ||||
intraperitoneal | 101 | 24 | 21 | 87.5 | 2 | 1 | 50 |
5 × 101 | 4 | 4 | 100.0 | ||||
102 | 43 | 43 | 100.0 | 6 | 6 | 100.0 | |
2.5 × 102 | 12 | 12 | 100.0 | ||||
103 | 19 | 19 | 100.0 | ||||
104 | 28 | 28 | 100.0 | 3 | 3 | 100.0 | |
106 | 16 | 16 | 100.0 | 2 | 2 | 100.0 | |
108 | 3 | 3 | 100.0 | 6 | 6 | 100.0 |