Table 2.

Maximum-likelihood parameter estimates.

route	model	parameter	estimate	95% CI
hamsters
IP	all	pp	0.21	0.12–0.36
intact	basic	pc	1.29 × 10−8	2.14 × 10−9–4.17 × 10−8
shaved	basic	pc	9.54 × 10−8	4.57 × 10−8–1.86 × 10−7
abraded	basic	pc	0.02	0.01–0.04
	mixture	α	0.24	1.2 × 10−3–0.95
		β	0.40	1.0 × 10−3–8.47
conjunctival	basic	pc	8.43 × 10−7	5.25 × 10−7–1.35 × 10−6
rats
IP	all	pp	0.07	0.02–0.35
abraded	basic	pc	0.02	1.4 × 10−3–0.03
	mixture	α	no unique solutiona
		β	no unique solutiona

^aAs explained in the electronic supplementary, text, this maximum-likelihood estimate (MLE) was defined as a limit, and did not take a single fixed value. The pair (α = 1114.675, β = 50000.00) was used to approximate the MLE in figures 2b,d and 3e.