Table 1.
Comparative Evaluation of MAA-Carbopol gel against Marketed formulation.
| Parameters | MAA-Carbopol gel |
Lotus gel (Marketed Preparation) | |||
|---|---|---|---|---|---|
| 0 day | 30 days | 60 days | 90 days | ||
| GSg (g/cm2) | 377 ± 2.4 | 361 ± 1.3 | 377 ± 2.4 | 371 ± 2.1 | 417 ± 2.1 |
| GT (°C) | 27.3 ± 0.2 | 26.1 ± 0.1 | 26.8 ± 0.3 | 27.1 ± 0.1 | 25.4 ± 0.2 |
| MT (°C) | 71.7 ± 1.0 | 70.1 ± 1.3 | 71.3 ± 1.2 | 71.6 ± 1.1 | 67.1 ± 0.1 |
| Apparent Viscosity (cp) at 80 °C | 62.7 ± 1.3 | 61.7 ± 1.2 | 61.7 ± 1.5 | 61.8 ± 1.2 | 58.7 ± 0.2 |
| MMS | 21.1 ± 1.1 | 20.1 ± 1.0 | 22.1 ± 0.2 | 21.1 ± 1.1 | 17.1 ± 1.5 |
| Ph | 6.2 ± 0.07 | 6.2 ± 0.02 | 6.1 ± 0.04 | 6.1 ± 0.03 | 6.1 ± 0.01 |
| Appearance | White | White | White | White | White |
| Homogeneity | Good | Good | Good | Good | Green |
| Spreading diameter (SD) after one minute (mm) | 57 ± 0.1 | 58 ± 0.1 | 57 ± 0.2 | 58 ± 0.1 | 62 ± 0.2 |
Gelling strength (GS), gelling temperature (GT), melting temperature (MT), molecular weight (MW) determination, spread ability (SA), mycosprine amino acid (MAA), MMs (Molecular mass), Viscosity(cp), Spreading diameter (SD).