Table 3.
Metaregression analyses with the potential modifiers of missed VNT rate and spared endoscopy rate.
| Explanatory variable | No. of observations | Coefficient (95% CI) | P-value |
|---|---|---|---|
| Missed VNT rate | |||
| Age (year) | 16 | 0.001 (−0.009 to 0.095) | 0.981 |
| Albumin (g/dL) | 14 | 0.013 (−0.166 to 0.168) | 0.987 |
| Alcoholic etiology (% of total) | 19 | 0.000 (−0.002 to 0.003) | 0.956 |
| ALT (U/l) | 14 | −0.001 (−0.012 to 0.011) | 0.919 |
| AST (U/l) | 13 | 0.000 (−0.028 to 0.028) | 0.984 |
| Bilirubin (mg/dL) | 13 | −0.034 (−0.135 to 0.128) | 0.956 |
| BMI (kg/m2) | 14 | −0.010 (−0.238 to 0.219) | 0.929 |
| Creatinine (mg/dL) | 12 | −0.007 (−0.330 to 0.317) | 0.992 |
| Gender (male%) | 20 | 0.000 (−0.003 to 0.003) | 0.959 |
| INR | 12 | −0.043 (−0.908 to 0.823) | 0.915 |
| Liver stiffness (kPa) | 21 | −0.001 (−0.004 to 0.040) | 0.952 |
| MELD score | 10 | −0.017 (−0.040 to 0.370) | 0.922 |
| NAFLD/NASH (% of total) | 17 | 0.000 (−0.002 to 0.002) | 0.889 |
| Platelet count (109 cells/L) | 21 | 0.000 (−0.013 to 0.012) | 0.961 |
| Viral etiology (% of total) | 22 | 0.000 (−0.001 to 0.001) | 0.935 |
| SER | |||
| Age (year) | 16 | 0.019 (0.012 to 0.037) | 0.038* |
| Albumin (g/dL) | 14 | 0.336 (0.004 to 0.667) | 0.048* |
| Alcoholic etiology (% of total) | 19 | 0.015 (−0.006 to 0.009) | 0.701 |
| ALT (U/l) | 14 | −0.003 (−0.005 to −0.001) | 0.047* |
| AST (U/l) | 13 | −0.006 (−0.010 to −0.001) | 0.028* |
| Bilirubin (mg/dL) | 13 | 0.084 (−0.058 to 0.225) | 0.219 |
| BMI (kg/m2) | 14 | −0.038 (−0.083 to 0.007) | 0.093 |
| Creatinine (mg/dL) | Conditions of the analysis were not met | ||
| Gender (male%) | 20 | −0.002 (−0.007 to 0.004) | 0.554 |
| INR | 12 | −0.753 (−1.831 to 0.325) | 0.151 |
| Liver stiffness (kPa) | 21 | −0.008 (−0.018 to 0.003) | 0.134 |
| MELD score | 10 | −0.013 (−0.059 to 0.033) | 0.541 |
| NAFLD/NASH (% of total) | 17 | 0.005 (0.001 to 0.009) | 0.001* |
| Platelet count (109 cells/L) | 21 | 0.003 (-0.001 to 0.005) | 0.050 |
| Viral etiology (% of total) | 22 | −0.002 (−0.004 to −0.000) | 0.046* |
*
Indicates a probability value (p) <0.05. AST, aspartate aminotransferase; ALT, alanine aminotransferase; BMI, body mass index; CI, confidence interval; INR, international normalized ratio; MELD, model for end-stage liver disease; NASH/NAFLD, non-alcoholic steatohepatitis/non-alcoholic fatty liver disease; VNT, varices needing treatment.