Table 4.
Population: patients suffering from cACLD (with an LS cut-off of 10 kPa) | |||||
Index test: Baveno VI criteria for ruling out VNTs (LS < 20 kPa and platelet count >150 × 109 cells/L) | |||||
Reference standard: Variceal screening endoscopy | |||||
Outcomes: Safety (i.e., missed VNT rate) and efficacy (i.e., SER) | |||||
Outcomes | No. of studies (patients) | Point estimate (95% confidence interval) | Importance | Quality of evidence | Comments |
Missed VNT rate | 13 (4,464) | 0.3% 0.1–0.6% | Critical | •••° moderate | Downgraded for risk of bias |
SER | 13 (4,464) | 32.8% 24.8–41.4% | Important | ••°° low | Downgraded for risk of bias and inconsistency |
cACLD, compensated advanced chronic liver disease; LS, liver stiffness; SER, spared endoscopy rate; VNTs, varices needing treatment.