Significantly modulated individual SPMs during STEMI.
Plasma from healthy volunteers (n = 10) and patients with stable CAD (n = 10) and STEMI (n = 15) were collected after MI onset. Repeated samples were drawn from STEMI patients. LM were obtained using LC-MS/MS. (a) Quantification of PD1, 10S,17S-diHDA, (b) PD2n-3 DPA, 10S,17SdiHDPA, and (c) RvD5n-3 DPA. Results are expressed as pg/ml and mean ± SEM *p < 0·05, **p < 0·01, ***p < 0·001 vs. STEMI baseline. #p < 0·05, ##p < 0·01, ###p < 0·001 for repeated measures ANOVA for STEMI-baseline, day 1, and day 8. LM, lipid mediators.