Fig. 5.

Aspirin triggered SPM biosynthesis during STEMI.

Plasma from healthy volunteers (n = 10) and patients with stable CAD (n = 10) and STEMI (n = 15) were collected after MI onset. Repeated samples were drawn from STEMI patients. LM were obtained using LC-MS/MS. (a) Biosynthetic pathways involved in AT-SPMs. (b) Quantification of prostaglandins, TxB₂, (c) AT-PD1 (d) AT-LXA₄. Results are expressed as pg/ml and as mean ± SEM. *p < 0·05, **p < 0·01, ***p < 0·001 vs. STEMI baseline. ^#p < 0·05, ^##p < 0·01, ^###p < 0·001 for repeated measures ANOVA for STEMI-baseline, day 1, and day 8. Refer to Table 1 for patient demographics.