Fig. 6.

Modulation of 5-LOX dependent mediators.

Plasma from healthy volunteers (n = 10) and patients with stable CAD (n = 10) and STEMI (n = 15) were collected after MI onset. Repeated samples were drawn from STEMI patients. LM were obtained using LC-MS/MS. (a) AA-derived 5-LOX products. (b) n-3 PUFA-derived 5-LOX products (c) Ratio of RvT4 to LTB₄. Results are expressed as pg/ml and as mean ± SEM. *p < 0·05, **p < 0·01, ***p < 0·001 vs. STEMI baseline. ^#p < 0·05, ^##p < 0·01, ^###p < 0·001 for repeated measures ANOVA for STEMI-baseline, day 1, and day 8.