Table 5.

P‐values of chronic toxicity for inhaled thymol based on 25 Category‐2 PAPs with Fisher exact test

Mouse organs and PAP Groups (Category‐2 PAPs)	Items	# of Occurrence, gx,				FET P ‐values per hypotheses (8a) to (8e)					Is thymol toxic? (meets all inequalities (6a‐6e)
	Treatment	G1	G2	G3	G4	g3 > g1	g3 > g2	g4 > g1	g4 > g2	g4 ≥ g3
	Dose, d	0	0	117	858	117 vs 0	117 vs 0	858 vs 0	858 vs 0	858 vs 117
	# of Mice	32	32	32	32	32/32	32/32	32/32	32/32	32/32
A. Lung Adenoma; Bronchiolealveolar Inflammation; Chronic Macrophages; Alveolar; Focal; Subpleural Metaplasia; Osseous Mineralization; Vessel	5 PAPs	3	0	0	4	1.000	n/a*	.500	.057	.057	No
B. Lymph Node, Bronchi Hyalinized Material; Medullary Cords; Increased High Endothelial Venules; Increased Lymphocytes; Cortex; Infiltrate; Neutrophils Focal.	4 PAPs	1	1	2	4	.500	.500	.177	.177	.336	No
C1. Nasal Turbinate Level I Eosinophilic Globules (Droplets); Nasal Cavity; Exudate; Neutrophils; Hemorrhage; Acute; Nasolacrimal Duct	3 PAPs	1	3	1	1	.754	.943	.754	.943	.754	No
C2. Nasal Turbinate Level II Eosinophilic Globules (Droplets); Nasal Cavity; Hyperplasia; Bowman's Gland; Lateral Wall/Turbinate; Hyperplasia; Squamous Epithelium; Nasolacrimal Duct; Increased Infiltrate; Mononuclear Cell; Dorsal Turbinate; Inflammation; Acute; Lateral Wall/Turbinate; Inflammation; Chronic; Septum.	6 PAPs	1	1	7	1	.027	.027	.754	.754	.998	No
C3. Nasal Turbinate Level III Eosinophilic Globules (Droplets); Nasal Cavity; Hyperplasia; Bowman's Gland; Lateral Wall/Turbinate; Hyperplasia; Bowman's Gland; Septum Inflammation; Chronic; Septum	4 PAPs	2	0	2	2	.694	.246	.694	.246	.694	No
C4. Nasal Turbinate Level IV Eosinophilic Globules (Droplets); Nasal Cavity; Eosinophilic Substance; Septum Exudate; Mucus/Hemorrhage	3 PAPs	0	1	0	2	n/a*	1.000	.245	.500	.246	No

^*No observation from both groups, therefore no P‐values were obtained.