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. Author manuscript; available in PMC: 2020 Jun 21.
Published in final edited form as: Analyst. 2019 May 22;144(12):3790–3799. doi: 10.1039/c9an00500e

Figure 3.

Figure 3.

(a) Data acquisition and processing procedure; scale bars (from top-left to bottom-right): 1000μm, 100μm, and 10μm. Multi-band Raman images for (b) human skin fibroblasts (scale bar: 20μm) and (c) pig alveolar macrophages (scale bar: 10μm). (d) Reference spectra for linear combination modelling. (e) Single-cell compositional correlation plot and histograms showing fibroblast population distributions; each data point represents a single cell. WT in black, NPC in red. (f) First two PCA loading spectra and PCA score distribution plots (WT in black, NPC in red). (g) Single-cell compositional correlation plot and histograms showing alveolar macrophage population distributions; each data point represents a single cell. Untreated control group in black, drug-treated group in green. (h) First two PCA loading spectra and PCA score distribution plots (untreated in black, drug-treated in green).