Table 1.
Transcriptome profiling of histamine‐related and signal transduction genes in post‐mortem spinal cords from sALS patient subgroups
| Histamine‐related process | Gene symbol human | sALS1 vs. Ctrl+ | sALS2 vs. Ctrl+ |
|---|---|---|---|
| Histamine receptors response | HRH1 | −1.3657919 | −3.3676426 |
| HRH3 | 3.3078184 | 3.2435715 | |
| Histamine transport/secretion | EDN1 | −1.3455846 | — |
| ADCYAP1 | 2.1645012 | 1.2958059 | |
| BTK | 1.620403 | — | |
| CCKBR | 2.0207274 | 1.3815044 | |
| SLC22A2 | — | −1.7292576 | |
| SNX4 | −1.4973569 | −2.0508032 | |
| SNX6 | −1.3490248 | −1.2742385 | |
| VAMP8 | −1.3397137 | — | |
| YWHAZ | 1.652496 | −1.4955612 | |
| Histamine metabolic process | HNMT | — | 1.2507114 |
| PRG3 | — | −1.3007661 | |
| Intracellular signal transduction | ADCY2 | 1.376056 | 1.6595138 |
| ADCY3 | −1.3174565 | — | |
| ADCY6 | 1.3229696 | — | |
| ADCY9 | — | 2.8711603 | |
| AKT1 | 1.2297583 | 1.4288182 | |
| AKT2 | −1.4742545 | — | |
| CREB1 | 1.403151 | 2.7520528 | |
| CREM | −1.9194763 | −1.822243 | |
| DRD4 | −1.7610718 | −1.7517854 | |
| GABRA1 | 1.3790314 | −1.9063799 | |
| GABRB1 | −1.3748144 | −1.313528 | |
| GABRB2 | −1.3764367 | −2.2042353 | |
| GABRG2 | — | −2.3212576 | |
| GNA11 | 1.2675852 | −1.2588073 | |
| GNAI1 | — | −1.2425077 | |
| GNAO1 | 2.0851884 | — | |
| GNAQ | 1.2491798 | — | |
| GNAS | −1.7503345 | −1.7303176 | |
| GNB1 | −1.3101016 | −1.4926312 | |
| GNB2 | 1.6231925 | — | |
| GNB4 | −1.5696274 | 1.3077484 | |
| GNG10 | −1.5117173 | — | |
| GNG11 | −1.661936 | — | |
| GNG13 | −1.6040359 | −1.5928824 | |
| GNG2 | — | −1.5869129 | |
| GNG3 | 4.5467305 | 2.6538045 | |
| GNG4 | — | 1.2450533 | |
| GNGT1 | 2.855986 | 1.8022374 | |
| IL10 | — | −1.382579 | |
| IL12B | 1.3056774 | — | |
| IL1B | — | −1.3257394 | |
| IL6 | — | −1.5675232 | |
| IRX3 | −1.2770016 | — | |
| ITPR1 | — | −1.5479783 | |
| MAP 2K2 | 1.297921 | — | |
| MAPK12 | 1.3404667 | — | |
| MAPK13 | 1.6014148 | 2.256803 | |
| MAPK14 | — | 1.7909265 | |
| MMP13 | — | 2.749664 | |
| MMP9 | — | −1.5295984 | |
| NFATC1 | −1.3547095 | −1.3149108 | |
| NFATC2 | −1.2919623 | −1.6587437 | |
| NFKB1 | −1.6059966 | −1.6690269 | |
| NFKB2 | — | −1.433936 | |
| PLCB1 | −1.3287859 | −1.4977577 | |
| PLCB3 | 1.526242 | — | |
| PRKACA | 1.3877281 | −1.8401401 | |
| PRKACB | — | −1.270291 | |
| PRKAR1A | 1.4079843 | −1.8058393 | |
| PRKAR2A | −1.447215 | −1.5083927 | |
| PRKCA | −1.3950349 | −1.2679613 | |
| RAF1 | −1.2660495 | −1.447958 | |
| RELA | −1.3689778 | −1.7076415 | |
| TNF | 1.350179 | — | |
| VCAM1 | −1.4938694 | — |
The table lists the principal histamine‐related and intracellular signal transduction genes differentially expressed in the spinal cord of two molecularly distinct subgroups of sALS patients,9 in comparison with individual controls. Expression levels are indicated as fold‐change values. Official Entrez Gene Symbols are used. HNMT, histamine N‐methyltransferase; sALS, sporadic amyotrophic lateral sclerosis.