Fig. 1.

Analysis of IQP-0528 (open) and TFV (striped) levels in a vaginal tissues, b vaginal fluids, and c rectal fluids from N = 6 macaques treated vaginally with 0.5 (black) or 1.5 ml (gray) IQB-4012 gel. Results shown for vaginal samples include pooled data from proximal, medial, and distal sites. Concentrations at each of these sites are listed in Table 2. One-way ANOVA test with Dunns post-test analysis was performed. Significant paired data sets (p < 0.05) were further analyzed ad-hoc using Wilcoxon matched-pairs signed-rank t test, and yielded p values < 0.0001 where indicated (*)