Table 3. Weight and MUAC gain velocity of children with SAM randomised to reduced or standard RUTF dose in unadjusted model.
| Outcome | Reduced RUTF | Standard RUTF | Difference (95% CI) |
p-value | ||
|---|---|---|---|---|---|---|
| Admission to Discharge | n | mean ± SD | n | mean ± SD | ||
| Weight gain velocity (g/kg/day) | ||||||
| ITT | 396 | 3.4 ± 3.1 | 389 | 3.4 ± 3.1 | 0.0 (−0.4 to 0.4) | 0.92 |
| PP1 | 200 | 4.3 ± 3.4 | 223 | 4.1 ± 3.6 | 0.2 (−0.5 to 0.8) | 0.58 |
| Recovered | 212 | 4.9 ± 2.6 | 221 | 4.9 ± 2.5 | −0.1 (−0.6 to 0.4) | 0.73 |
| Referred | 74 | 0.9 ± 3.4 | 78 | 0.4 ± 3.0 | 0.5 (−0.6 to 1.5) | 0.37 |
| Defaulted | 46 | 2.5 ± 1.9 | 26 | 2.7 ± 2.7 | −0.3 (−1.3 to 0.8) | 0.64 |
| MUAC gain velocity (mm/week) | ||||||
| ITT | 398 | 1.8 ± 1.8 | 390 | 1.9 ± 1.9 | −0.1 (−0.3 to 0.2) | 0.58 |
| PP1 | 201 | 2.4 ± 2.1 | 224 | 2.4 ± 2.1 | −0.1 (−0.5 to 0.3) | 0.78 |
| After Two Weeks | ||||||
| Weight gain velocity (g/kg/day) | ||||||
| ITT | 376 | 2.3 ± 2.6 | 368 | 2.7 ± 2.9 | −0.4 (−0.8 to −0.02) | 0.041 |
| PP1 | 188 | 2.7 ± 2.9 | 207 | 3.1 ± 3.4 | −0.4 (−1.0 to 0.2) | 0.22 |
| MUAC gain velocity (mm/week) | ||||||
| ITT | 378 | 1.1 ± 1.7 | 368 | 1.4 ± 1.9 | −0.2 (−0.5 to −0.001) | 0.051 |
| PP1 | 189 | 1.6 ± 1.9 | 207 | 1.8 ± 2.2 | −0.2 (−0.6 to 0.2) | 0.27 |
Data are mean ± SD and mean difference (95% CI) when using linear mixed models, with study site and team as random effects.
1PP (per protocol) includes children that had no missed visits, that consumed >50% of daily dose throughout treatment, that were not falsely discharged, and that received the correct RUTF dose throughout treatment.
Abbreviations: ITT, intention to treat; MUAC, mid-upper arm circumference; PP, per protocol; RUTF, ready-to-use therapeutic food; SAM, severe acute malnutrition.