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In cancer cells, the activated SMO and GLI could be suppressed by ITZ, these lead to the inhibition of target genes including Sox9/mTOR, cyclin D1, Wnt/β-catenin, Bcl-2/cyt C, PI3K/AKT/mTOR, vascular endothelial growth factor receptor 2 (VEGFR2), multidrug resistance protein 1 (ABCC1) to inhibit the growth and proliferation of many cancers in vivo and in vitro, arrest cell cycle, inhibit angiogenesis, and induce apoptosis and autophagy.
