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. 2019 Aug 27;14(8):e0221132. doi: 10.1371/journal.pone.0221132

Fig 2. Effect of curcumin and the derivatives on the amplitude of the whole-cell current in the absence and presence of derivatives.

Fig 2

A are the AMPAR recorded upon 500 ms application of 10 mM glutamate to whole-cell recording from HEK293 cells expressing homomeric GluA2 alone or in combination with the derivatives. B are the AMPAR recorded upon 500 ms application of 10 mM glutamate to whole-cell recording from HEK293 cells expressing heteromeric GluA2/3 alone or in combination with the derivatives. C-D Inhibition assays of different derivatives on GluA2 and GluA2/3. The whole-cell current recording was conducted at −60 mV, pH 7.4, and 22 °C. Graphs summarize weighted time constants for activation. Data shown are mean ± SEM; n = 6 (number of patch cells in the whole-cell configuration). Significance (one-way ANOVA): * p < 0.05; ** p < 0.01; *** p < 0.001; ns, not significant.