Figure 4.

Time-sensitive urinary excretion of metabolites of two unsaturated aldehydes, acrolein (3HPMA) and crotonaldehyde (HPMMA), from mice exposed to e-cigarette aerosols or reference tobacco cigarette smoke. A) Classic Tobacco (CT); B) Magnificent Menthol (MM); C) KY Reference Cigarette, 3R4F. Values are means±SE (n=5 different mice per exposure). *P<0.05 between 0–1h level – baseline for CT and MM; Conditions of 4h (e-cigarette) or 6h (3R4F) exposure are shown in Suppl. Fig. 1 & Suppl. Table 2.