Figure 5.

Time-sensitive urinary excretion of nicotine (NIC) and its metabolites, cotinine (COT) and trans-3-hydroxycotinine (3HC), from mice exposed to e-cigarette aerosols or reference tobacco cigarettes. A) Classic Tobacco (CT); B) Magnificent Menthol (MM); C) KY Reference Cigarette, 3R4F, shown as positive control. Values are means±SE (n=5 different mice per e-cigarette exposure and n=3 for MCS exposure). Conditions of 4h (e-cigarette) or 6h (3R4F) exposure are shown in Suppl. Fig. 1 and Suppl. Table 2.