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. 2019 Aug 20;93(8):e791–e803. doi: 10.1212/WNL.0000000000007966

Figure 2. Sensitivity analyses.

Figure 2

(A) Total cerebral volume (TCV). (B) Cortical thickness (CT). (C) White matter hyperintensity volume (WMHV). (D). Subclinical brain infarct (SBI). Points represent β coefficients from multivariable linear regression models or odds ratios from logistic regression models (for SBI). Models adjusted for covariates from model 2: age, sex, race/ethnicity, education, years from baseline to MRI, total intracranial volume (for TCV and WMHV), smoking status, moderate to heavy physical activity, moderate alcohol consumption, systolic blood pressure, diastolic blood pressure, antihypertensive medication use, blood glucose, diabetic medication use, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and cholesterol-lowering medication. For WMHV, estimates transformed to represent percent change in WMHV per 1 unit increase in the predictor. Green = subsample of those cognitively unimpaired (n = 1,087). Blue = subsample of original Northern Manhattan Study cohort members (n = 1,090). Purple = analyses conducted in ×10 multiply imputed datasets. BMI = body mass index; WC = waist circumference; MI = myocardial infarction; WHR = waist-to-hip ratio.