Table 2.

A2ML1 Genotypes and Otitis Media Status for 135 Indigenous Filipinos

A2ML1 genotype	Normal otoscopy	Otitis media†	Total
Wildtype	27	22	49
Heterozygous, duplication	17	36	53
Heterozygous, splice	5	10	15
Compound heterozygous	1	8	9
Homozygous, duplication	3	5	8
Homozygous, splice	0	1	1
Total with variant‡	26	60	86
Overall total	53	82	135

^†Of 60 A2ML1 variant carriers with otitis media, 22 (36.7%) have chronic otitis media, 23 (38.3%) with healed otitis media, 14 (23.3%) with effusive otitis media, and 1 with acute otitis media based on last exam. In contrast, among 22 wildtype individuals with otitis media, 9 (40.9%) have chronic otitis media, 5 (22.7%) with healed otitis media, another 5 (22.7%) with effusive otitis media and 3 (13.6%) with acute otitis media. Fifteen of the 22 wildtype individuals with otitis media carry the FUT2 c.604C>T (p.Arg202*) variant which also plays a role in otitis media susceptibility (Santos-Cortez et al. 2018; Supp. Fig. S3).

^‡The Fisher exact odds ratio for an A2ML1 variant carrier having otitis media is 2.8 (95%CI: 1.3, 6.2; p=0.006).