Table 3.
Top 41 genes correlated with A2ML1 in Colorado patients and their known role in mucosal, epithelial or infectious traits
| Gene | Spearman R | p-value | Known Role in Mucosa/Infection/Epithelium | Reference |
|---|---|---|---|---|
| EMP1 | 0.919 | 3.30E-06 | Downregulated in nasal polyps | Yu et al. 2013 |
| SPRR3 | 0.903 | 3.28E-06 | Upregulated in chronic rhinosinusitis | Ramakrishnan et al. 2017 |
| RND3 | 0.896 | 3.19E-06 | Forms confluent layer of HMEECs | Mulay et al. 2016 |
| CSTB | 0.887 | 3.02E-06 | Upregulated in gingival epithelial cells after contact with Fusobacterium nucleatum | Yin & Dale 2007 |
| MUC21 | 0.886 | 3.00E-06 | Induced by RSV and hMPV | Banos-Lara et al. 2015 |
| RNR2 | 0.880 | 2.84E-06 | Expressed in olfactory mucosa | Bergstrom et al. 2007 |
| MTRNR2L8 | 0.876 | 2.73E-06 | -- | -- |
| KRT4 | 0.876 | 2.73E-06 | Upregulated in cholesteatoma | Britze et al. 2014 |
| PPL | 0.873 | 2.60E-06 | Autoimmune target in IPF | Taille et al. 2011 |
| SPINK5 | 0.870 | 2.50E-06 | Otitis media in Netherton syndrome | Renner et al. 2009 |
| TMPRSS11B | 0.869 | 2.47E-06 | Expressed in squamous epithelia of cervix, esophagus and oral cavity | Miller et al. 2014 |
| ECM1 | 0.867 | 2.40E-06 | Mucosal defect in lipoid proteinosis | Mirancea et al. 2007 |
| ERO1L | 0.867 | 2.40E-06 | High expression in gastric cancer with poor prognosis | Seol et al. 2016 |
| LPIN1 | 0.866 | 2.36E-06 | Downregulated due to high-fat diet along with changes in gastrointestinal mucosa | Zhou et al. 2016 |
| S100A10 | 0.862 | 2.23E-06 | Interaction with TRPV6 in airway and gut epithelia | Borthwick et al. 2008 |
| KRT13 | 0.858 | 2.09E-06 | Mutations lead to white sponge naevus in buccal mucosa | Liu et al. 2011 |
| TMPRSS11D | 0.858 | 2.09E-06 | Protease in airway epithelium | Menou et al. 2017 |
| AHNAK | 0.851 | 1.89E-06 | Upregulated in otitis media | This report |
| SPRR1B | 0.848 | 1.82E-06 | Upregulated in chronic rhinosinusitis | Ramakrishnan et al. 2017 |
| SCEL | 0.847 | 1.80E-06 | Forms cornified envelope in stratified squamous epithelium | Baden et al. 2005 |
| RNR1 | 0.845 | 1.76E-06 | -- | -- |
| CRNN | 0.843 | 1.73E-06 | Downregulated in esophageal cancer | Pawar et al. 2013 |
| CAST | 0.840 | 1.71E-06 | Decreases influenza A infection | Blanc et al. 2016 |
| PABPC1 | 0.837 | 1.71E-06 | Interaction with HSV-1 proteins | Dobrikova et al. 2010 |
| ADAM9 | 0.836 | 1.72E-06 | Increased in COPD bronchial cells | Wang et al. 2018 |
| ATF6B | −0.836 | 1.72E-06 | -- | -- |
| KRT78 | 0.834 | 1.74E-06 | Expressed in squamous epithelia | Langbein et al. 2016 |
| TGM3 | 0.833 | 1.76E-06 | Cross-links with HPV proteins | Brown et al. 2006 |
| LMO7 | 0.832 | 1.78E-06 | Upregulated by H.pylori in gastric cells | Lim et al. 2003 |
| AIM1 | 0.831 | 1.81E-06 | Expressed in EBV-infected cells | Cahir-McFarland et al. 2004 |
| ANXA1 | 0.831 | 1.81E-06 | Regulates intestinal mucosal injury, inflammation and repair | Babbin et al. 2008 |
| FAM129B | 0.831 | 1.81E-06 | Knockout results in delayed healing of wounded skin; keratinocyte-expressed | Oishi et al. 2012 |
| SEMA3F | −0.831 | 1.81E-06 | Regulates neurite growth in lingual epithelium | Vilbig et al. 2004 |
| ANXA2 | 0.830 | 1.84E-06 | Increased bacterial opsonization and clearance in otitis media | Renner et al. 2016 |
| MAL | 0.830 | 1.84E-06 | Methylated in dysplastic cervix | Mersakova et al. 2014 |
| EHF | 0.823 | 2.21E-06 | Regulates airway gene expression | Fossum et al. 2017 |
| ERGIC2 | 0.823 | 2.21E-06 | -- | -- |
| MYO5B | 0.820 | 2.47E-06 | Mutation causes intestinal microvillus defects | Muller et al. 2008 |
| SASH1 | 0.816 | 2.91E-06 | Mutation causes lentiginous skin phenotypes | Zhang et al. 2016 |
| FLG | 0.813 | 3.34E-06 | Lower expression in cholesteatoma | Nguyen et al. 2014 |
| KLK13 | 0.810 | 3.85E-06 | In periodontitis Porphyromonas gingivalis proteases degrade SPINK6 resulting in loss of KLK13 inhibition | Plaza et al. 2016 |
HMEEC, human middle ear epithelial cells; RSV, respiratory syncytial virus; hMPV, human metapneumovirus; IPF, idiopathic pulmonary fibrosis; HSV-1, herpes simplex virus-1; COPD, chronic obstructive pulmonary disease; HPV, human papilloma virus; EBV, Epstein-Barr virus.