Table 1. Clinical course of HoFH patients undergoing liporprotein apheresis treatment.

	Age at diagnosis (y.o.)	Age at the introduction of LDL apheresis (y.o.)	Cardiovascular finding
39F	4	4	Atherosclerosis in carotid artery progressed after pregnancy
30F	1	5	No atherosclerotic finding
43F	1	6	Angina pectoris occurred at 2 years, total occlusion was apparent in the left main trunk at 5 years, CABG was performed at 10 and 15 years, PCI was performed at 24 years, and aortic valve replacement and CABG were performed at 41 years
33M	0	6	Deformation of the aortic valve at 5 years and aortic valve stenosis was slightly improved at 15 years, but aortic valve replacement was performed at 30 years
44F	3	9	RCA total occlusion was apparent at 25 years
47M	8	12	Deformation of the aortic valve at 9 years, aortic valve regurgitation was apparent at 19 years, and aortic valve replacement was performed at 30 years
52M	5	19	CABG was performed at 40 years
35F	3	22	CABG was performed for triple-vessel disease at 18 years
49F	unknown	22	CABG was performed at 18 years. At 49 years, the patient died from heart failure
31F	unknown	25	Aortic valve stenosis at 29 years and death from MI at 31 years
29M	unknown	27	Patient died from MI at 29 years
44M	34	34	Multiple coronary artery regions with 50% stenosis
66M	30	30	Patient underwent 7 PCIs over 30 years
45F	36	36	Patient died from peritonitis at 45 years
54F	3	47	Patient had 50% stenosis in coronary arteries
68F	52	52	CABG was performed at 57 years
24M	22	22	CABG was performed at 22 years
72F	37	65	CABG and aortic valve replacement were performed at 64 years

CABG: coronary artery bypass graft surgery, PCI: percutaneous coronary intervention, RCA: right coronary artery, MI: myocardial infarction