Table 1.
Columns are described here from left to right: In the left column, a list of genes, categorized by enzyme function that were on the qPCR array plate from Qiagen. The second column from the left has Refseq identifications for each mRNA assayed in the same order that gene names appear. In the third column from the left, gene functional group is provided. The fold change for genes with a significant uncorrected p-value is indicated in the third column from the right. The second column from the right has p values for genes with p < 0.05 using the paired two-tailed t-test. In the far right column are corrected p-values (using the Benjamini/Hochberg FDR) for genes that were p < 0.05 using the paired two-tailed t-test.
| Gene Names | Refseqs | Function Group | Fold Change | P Value | Corrected P Value |
|---|---|---|---|---|---|
| KDM1A, KDM4A, KDM4C, KDM5B, KDM5C, KDM6B, MBD2 | NM_015013, NM_014663, NM_015061, NM_006618, NM_004187, NM_001080424, NM_003927 | Demethylase | MBD2: 1.20 | MBD2: 0.00065 | MBD2: 0.049 |
| DNMT1, DNMT3A, DNMT3B | NM_001379, NM_022552, NM_006892 | DNMT | DNMT1: 1.25 | DNMT1: 0.0060 | DNMT1: 0.225 |
| ATF2, CDYL, CIITA, CSRP2BP, ESCO1, ESCO2, HAT1, KAT2A, KAT2B, KAT5, KAT6A, KAT6B, KAT7, KAT8, NCOA1, NCOA3, NCOA6 | NM_001880, NM_004824, NM_000246, NM_020536, NM_052911, NM_001017420, NM_003642, NM_021078, NM_003884, NM_006388, NM_006388, NM_006766, NM_012330, NM_007067, NM_032188, NM_003743, NM_181659, NM_014071 | HAT | KAT7: 1.34 | KAT7: 0.04 | KAT7: 0.311 |
| HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, HDAC9, HDAC10, HDAC11 | NM_004964, NM_001527, NM_003883, NM_006037, NM_005474, NM_006044, NM_001098416, NM_018486, NM_178425, NM_032019, NM_024827 | HDAC | HDAC4: 1.31 HDAC5: 1.28 HDAC6: 1.36 HDAC7: 1.49 |
HDAC4: 0.04 HDAC5: 0.04 HDAC6: 0.02 HDAC7: 0.04 |
HDAC4: 0.472 HDAC5: 0.299 HDAC6: 0.507 HDAC7: 0.413 |
| CARM1, DOT1L, EHMT2, KMT2A, KMT2C, PRMT1, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SETDB2, SMYD3, SUV39H1 | NM_199141, NM_032482, NM_006709, NM_005933, NM_170606, NM_001536, NM_001535, NM_005788, NM_006109, NM_018137, NM_019023, NM_019854, NM_031915, NM_022743, NM_003173 | HMT | DOT1L: 1.58 PRMT2: 1.35 PRMT5: 1.18 |
DOT1L: 0.03 PRMT2: 0.03 PRMT5: 0.04 |
DOT1L: 0.506 PRMT2: 0.513 PRMT5: 0.365 |
| ASH1L, KMT2E, NSD1, SETD1A, SETD1B, SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETD8, SETDB1, SUV420H1, WHSC1 | NM_018489, NM_182931, NM_022455, NM_014712, NM_015048, NM_014159, NM_199123, NM_017438, NM_001080517, NM_024860, NM_030648, NM_020382, NM_012432, NM_016028, NM_007331 | HMT Activity (SET Domain Proteins) | SETD4: 1.31 | SETD4: 0.04 | SETD4: 0.332 |
| AURKA, AURKB, AURKC, NEK6, PAK1, RPS6KA3, RPS6KA5 | NM_003600, NM_004217, NM_003160, NM_014397, NM_002576, NM_004586, NM_004755 | Phosphorylase | NONE | NONE | NONE |
| DZIP3, MYSM1, RNF2, RNF20, UBE2A, UBE2B, USP16, USP21, USP22 | NM_014648, NM_001085487, NM_007212, NM_019592, NM_003336, NM_003337, NM_006447, NM_012475, NM_015276 | Ubiquitinase | NONE | NONE | NONE |
| ACTB, B2M, GAPDH, HPRT1, RPLP0 | NM_001101, NM_004048, NM_002046, NM_000194, NM_001002, | Housekeeping Gene | N/A | N/A | N/A |
| HGDC | SA_00105 | Genomic DNA | N/A | N/A | N/A |