Fig. 6.

Proposed model for the role of LAIR2 in MF/SS pathogenesis. a) MF/SS cells that produce low/no LAIR2, such as in the Sensitive group, would still bind collagen through LAIR1, causing inhibitory signaling through LAIR1 ITIM domains. LAIR1-mediated inhibitory signaling could decrease proliferation, immune response, and inflammation. b) MF/SS cells that produce high levels of LAIR2, such as in the Resistant group, would have decreased binding of LAIR1 to collagen, causing decreased inhibitory ITIM signaling. Loss of LAIR1-inhibitory signaling could promote migration and proliferation of MF/SS cells and increased inflammation in the tumor microenvironment through decreased inhibitory signaling in local benign T and NK cells.