TABLE 2.
Summary of results for LDBio Aspergillus ICT IgG-IgM test and routine serologya
| Test | % sensitivity (95% CI) |
% specificity (95% CI) (healthy controls [n = 148])c |
Youden's index (all sera [n = 302])d |
DOR (95% CI) (all sera [n = 302]) |
||
|---|---|---|---|---|---|---|
| All CPA (n = 154) |
High positive (n = 11)b |
Seronegative (n = 10)b |
||||
| LDBio ICT | 91.6 (86.0, 95.4) | 100 (71.5, 100) | 90.0 (55.5, 99.8) | 98.0 (94.2, 99.6) | 0.896 | 524 (146, 1,879) |
| ImmunoCAP | 80.5 (73.4, 86.5) | 100 (71.5, 100) | 0 (0, 30.9) | NAe | NA | NA |
| McNemar's (P value) | 0.007 | NA | ||||
a
Results are reported against the cutoff of 40 mgA/liter recommended for use in United Kingdom laboratories at the time of publication.
b
ImmunoCAP results were used to define the “high positive” and “seronegative” groups.
c
Equivocal results (n = 2) were excluded from analysis.
d
Youden's index = sensitivity + specificity − 1.
e
NA, not applicable.