TABLE 2.
Carbapenemase type | GenePOC Carba assay |
Xpert Carba-R assay |
||||
---|---|---|---|---|---|---|
Sensitivity (95% CI) (%) | Specificity (95% CI) (%) | Youden index | Sensitivity (95% CI) (%) | Specificity (95% CI) (%) | Youden index | |
All carbapenemases (n = 139) | 100 (97.3–100) | 100 (91.8–100) | 1 | 96.4 (91.9–98.5) | 100 (91.8–100) | 0.96 |
Ambler class A (n = 13) | 100 (77.2–100) | 100 (77.2–100) | ||||
KPC (n = 13) | 100 (77.2–100) | 100 (77.2–100) | ||||
KPC-2 (n = 11) | 100 | 100 | ||||
KPC-3 (n = 2) | 100 | 100 | ||||
Ambler class B (n = 86) | 100 (95.7–100) | 94.2 (87.1–97.5) | ||||
NDM (n = 29) | 100 (88.3–100) | 100 (88.3–100) | ||||
NDM-1 (n = 19) | 100 | 100 | ||||
NDM-3 (n = 1) | 100 | 100 | ||||
NDM-4 (n = 1) | 100 | 100 | ||||
NDM-5 (n = 3) | 100 | 100 | ||||
NDM-7 (n = 2) | 100 | 100 | ||||
NDM-8 (n = 1) | 100 | 100 | ||||
NDM-9 (n = 2) | 100 | 100 | ||||
VIM (n = 48) | 100 (92.6–100) | 100 (92.6–100) | ||||
VIM-1 (n = 23) | 100 | 100 | ||||
VIM-2 (n = 4) | 100 | 100 | ||||
VIM-4 (n = 5) | 100 | 100 | ||||
VIM-5 (n = 1) | 100 | 100 | ||||
VIM-26 (n = 2) | 100 | 100 | ||||
VIM-27 (n = 1) | 100 | 100 | ||||
VIM-31 (n = 1) | 100 | 100 | ||||
VIM-39 (n = 3) | 100 | 100 | ||||
VIM-46 (n = 1) | 100 | 100 | ||||
VIM-51 (n = 1) | 100 | 100 | ||||
VIM-52 (n = 1) | 100 | 100 | ||||
VIM-54 (n = 1) | 100 | 100 | ||||
VIM-56 (n = 1) | 100 | 100 | ||||
VIM-58 (n = 1) | 100 | 100 | ||||
VIM-59 (n = 1) | 100 | 100 | ||||
VIM-1-like (n = 1) | 100 | 100 | ||||
IMP (n = 9) | 100 (70.1–100) | 44.4 (18.9–73.3) | ||||
IMP-1 (n = 2) | 100 | 100 | ||||
IMP-4 (n = 1) | 100 | 100 | ||||
IMP-8 (n = 1) | 100 | 0 | ||||
IMP-13 (n = 1) | 100 | 0 | ||||
IMP-14 (n = 1) | 100 | 0 | ||||
IMP-22 (n = 1) | 100 | 0 | ||||
IMP-28 (n = 1) | 100 | 100 | ||||
IMP-50 (n = 1) | 100 | 0 | ||||
Ambler class D (n = 40) | 100 (91.2–100) | 100 (91.2–100) | ||||
OXA-48-like (n = 40) | 100 (91.2–100) | 100 (91.2–100) | ||||
OXA-48 (n = 22) | 100 | 100 | ||||
OXA-162 (n = 4) | 100 | 100 | ||||
OXA-181 (n = 4) | 100 | 100 | ||||
OXA-204 (n = 1) | 100 | 100 | ||||
OXA-232 (n = 4) | 100 | 100 | ||||
OXA-244 (n = 2) | 100 | 100 | ||||
OXA-245 (n = 2) | 100 | 100 | ||||
OXA-370 (n = 1) | 100 | 100 |