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. 2019 Aug 26;57(9):e00597-19. doi: 10.1128/JCM.00597-19

TABLE 2.

Performance of the two assays for detection of carbapenemase production

Carbapenemase type GenePOC Carba assay
Xpert Carba-R assay
Sensitivity (95% CI) (%) Specificity (95% CI) (%) Youden index Sensitivity (95% CI) (%) Specificity (95% CI) (%) Youden index
All carbapenemases (n = 139) 100 (97.3–100) 100 (91.8–100) 1 96.4 (91.9–98.5) 100 (91.8–100) 0.96
Ambler class A (n = 13) 100 (77.2–100) 100 (77.2–100)
    KPC (n = 13) 100 (77.2–100) 100 (77.2–100)
        KPC-2 (n = 11) 100 100
        KPC-3 (n = 2) 100 100
Ambler class B (n = 86) 100 (95.7–100) 94.2 (87.1–97.5)
    NDM (n = 29) 100 (88.3–100) 100 (88.3–100)
        NDM-1 (n = 19) 100 100
        NDM-3 (n = 1) 100 100
        NDM-4 (n = 1) 100 100
        NDM-5 (n = 3) 100 100
        NDM-7 (n = 2) 100 100
        NDM-8 (n = 1) 100 100
        NDM-9 (n = 2) 100 100
    VIM (n = 48) 100 (92.6–100) 100 (92.6–100)
        VIM-1 (n = 23) 100 100
        VIM-2 (n = 4) 100 100
        VIM-4 (n = 5) 100 100
        VIM-5 (n = 1) 100 100
        VIM-26 (n = 2) 100 100
        VIM-27 (n = 1) 100 100
        VIM-31 (n = 1) 100 100
        VIM-39 (n = 3) 100 100
        VIM-46 (n = 1) 100 100
        VIM-51 (n = 1) 100 100
        VIM-52 (n = 1) 100 100
        VIM-54 (n = 1) 100 100
        VIM-56 (n = 1) 100 100
        VIM-58 (n = 1) 100 100
        VIM-59 (n = 1) 100 100
        VIM-1-like (n = 1) 100 100
    IMP (n = 9) 100 (70.1–100) 44.4 (18.9–73.3)
        IMP-1 (n = 2) 100 100
        IMP-4 (n = 1) 100 100
        IMP-8 (n = 1) 100 0
        IMP-13 (n = 1) 100 0
        IMP-14 (n = 1) 100 0
        IMP-22 (n = 1) 100 0
        IMP-28 (n = 1) 100 100
        IMP-50 (n = 1) 100 0
Ambler class D (n = 40) 100 (91.2–100) 100 (91.2–100)
    OXA-48-like (n = 40) 100 (91.2–100) 100 (91.2–100)
        OXA-48 (n = 22) 100 100
        OXA-162 (n = 4) 100 100
        OXA-181 (n = 4) 100 100
        OXA-204 (n = 1) 100 100
        OXA-232 (n = 4) 100 100
        OXA-244 (n = 2) 100 100
        OXA-245 (n = 2) 100 100
        OXA-370 (n = 1) 100 100