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. 2019 Aug 27;9:12433. doi: 10.1038/s41598-019-48825-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Scatter plots of the integrity of EZ quantified by two graders. Comparison of the measurement of the rEZ index between 2 graders are shown. (a) rEZc, the ICC value was equal to 0.938 (95%CI: 0.916–0.945, p < 0.001). (b) rEZave, the ICC was 0.979 (95% CI: 0.936–0.987, p < 0.001). EZ: ellipsoid zone, rEZ: residual ellipsoid zone, rEZc: the rEZ index of the central horizontal line scan across the fovea, ICC: intraclass correlation coefficient, CI: confidence interval, rEZave: the average of rEZ indices of 13 line scans within 3 × 3-mm area.