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. 2019 Aug 27;9:12433. doi: 10.1038/s41598-019-48825-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fundus photograph with visual sensitivities and OCT images in a representative case. Right eye of a 61-year-old man with resolved CSC. The logMAR VA was −0.0792, MS was 26.3. rEZc, rEZave and rEZ1mm were 0.906, 0.971 and 0.829, respectively. (a) Retinal sensitivity measurements with the MP-3 microperimeter superimposed onto a fundus photograph. Twenty-five measurement points are located within central 12° of the macula. (b,c) An OCT image obtained with Spectralis OCT. EZ is located between ELM and RPE. (d,e) A binarized OCT image. OCT images were binarized using the Niblack method with ImageJ software. Blue arrows indicate the location of ELM, EZ and RPE. The EZ within 3 mm across the fovea was traced by hand (blue line). OCT: optical coherence tomography, CSC: central serous chorioretinopathy, LogMAR: logarithm of the minimum angle of resolution, VA: visual acuity, MS: mean sensitivity, rEZc: the rEZ index of the central horizontal line scan across the fovea, rEZave: the average of rEZ indices of 13 line scans within 3 × 3-mm area, rEZ1mm: the average of rEZ indices of 5 line scans within 1 × 1-mm area of the fovea, EZ: ellipsoid zone, ELM: external limiting membrane, RPE: retinal pigment epithelium.