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. 2019 Aug 27;9:12405. doi: 10.1038/s41598-019-48914-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Drugs that increase Tg(per3:luc) luminescence circadian period length. Compounds that increased period length include CK1 inhibitor SSR112050 (A), AMPK activator AICAR (B), sirtuin activator resveratrol (C), PI3K inhibitor GNE 490 (D), P38 MAPK inhibitor TAK 715 (E) and CDK1 inhibitor bohemine (F). Black and gray represent drug and DMSO control, respectively. *P < 0.05, **P < 0.01, ***P < 0.001 by ANOVA with Tukey’s test.