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. 2019 Aug 27;9:12405. doi: 10.1038/s41598-019-48914-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Drugs that affect Tg(per3:luc) luminescence circadian phase. Glycine receptor agonist taurine (A) and glycine transporter inhibitor ALX 5407 (B) caused phase advances. SSRI citalopram (C) and D2 receptor antagonist triflupromazine (D) induced phase advances. L-type calcium channel inhibitor manidipine (E) and Kv1.3 shaker channel inhibitor psora 4 (F) induced phase advances. Psora 4 only affected phase during the first circadian oscillation (F). *P < 0.05, **P < 0.01, ***P < 0.001 by ANOVA with Tukey’s test.