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. 2019 Aug 27;9:12405. doi: 10.1038/s41598-019-48914-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Drugs that affect Tg(per3:luc) luminescence circadian amplitude do not necessarily similarly affect locomotor activity circadian amplitude. Anti-inflammatory drug cyclosporin (A) and NF-κB inhibitor Ro 106-9920 (D) increase and decrease larval per3:luc luminescence amplitude, respectively. However, both compounds increase locomotor activity circadian amplitude in LD (B,E) and in entrained animals shifted to DD (C,F). Number of animals: (B) DMSO n = 36, cyclosporin n = 39. (C) DMSO n = 45, cyclosporin n = 34. (E) DMSO n = 45, Ro 106-9920 n = 37. (F) DMSO n = 45, Ro 106-9920 n = 40. *P < 0.05, **P < 0.01, ***P < 0.001 by ANOVA with Tukey’s test. Luminescence data shown in (A) is the same as that shown in Fig. 4A.