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. 2019 Aug 27;9:12421. doi: 10.1038/s41598-019-48741-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GSEA using microarray data sets from Gata6^−/− LPM. The 624 up-regulated and the 857 down-regulated DEGs in SerpinB2^R380A RPM were compared by GSEA with 3 microarray data sets that compared LPM from Gata6^+/+ and Gata6^−/− mice; (a) GSE47049, (b) GSE56684 and (c) GSE37448. GSEAs showing significant counter-regulation (i.e. up in SerpinB2^R380A and down in Gata6^−/− or down in SerpinB2^R380A and up in Gata6^−/−) are indicated with red p values. Heat maps of core enriched genes showing counter-regulation are shown for (a,b) and for Down DEGs in (c), which showed counter-regulation that did not reach significance (q = 0.094). Up DEGs in (c) showed co-regulation (positive NES score) indicating no significant counter-regulation. The core enriched genes illustrated by the heat maps are listed in Table S1h.