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Schematic representation of the proposed effects of RNA on rPrP aggregation. Upon reaching the critical concentration rPrP forms very small aggregates in the absence of RNA. When the protein is in much excess over RNA (high rPrP to RNA ratio), rPrP aggregates profusely, sequestering the RNA. Alternatively, at low protein to RNA ratio, rPrP aggregation decreases and formation of oligomeric species, capable of nucleating de novo rPrP aggregation, prevails.
