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. 2019 Jul 24;4(4):495–505. doi: 10.1016/j.jacbts.2019.03.004

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Uniaxial Passive Mechanics of Native and Re-Cellularized Myocardial Strips

(A) Force response resulting from slow stretch of an EHT under physiological conditions paced at 1 Hz. (B) Tissue was uniaxially stretched at a rate of 0.25% muscle lengths per second to a final stretch of 10%. (C) Extracted diastolic force curve from native tissue and EHTs show the force-stretch relationship, with stiffness at 9% stretch extracted using finite difference calculation for comparison. (D) Typical image of a porcine myocardium laser-cut native tissue sample. (E) Native non-decellularized tissue stiffness of MUT samples (n = 3) were significantly higher than that of the WT samples (n = 6) (p = 0.0092). (F) Typical image of an EHT formed by re-seeding decellularized porcine myocardium with healthy iPSC-CMs. (G) Passive stiffness of EHTs created from MUT tissue (n = 6) were significantly higher than those created from WT tissue (n = 6) (p = 0.0203). ∗p < 0.05, ∗∗p < 0.01. Abbreviations as in Figures 1 and 2.