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. 2019 Jul 24;4(4):495–505. doi: 10.1016/j.jacbts.2019.03.004

Figure 4.

Figure 4

Active Mechanics of EHTs Created From Healthy and Diseased Tissue Scaffolds

(A) Representative twitch force traces measured in EHTs created out of WT and MUT extracellular matrix (ECM). (B) R403Q mutant ECM EHTs showed a 33% increase in early relaxation (time from peak tension to 50% relaxation [RT50]; p = 0.0022). (C) Time to peak tension (TTP) in MUT ECM EHTs was 24% slower (p = 0.0014). (D) MUT ECM EHTs showed a 24% increase in the normalized time tension integral (nTTI; p = 0.0043). (E) Peak force was significantly increased in MUT EHTs (p = 0.0411). (F) Cross-sectional area was significantly increased in MUT EHTs (p = 0.0411). (G) Peak stress was not significantly different (p = 0.054). ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001. Abbreviations as in Figures 1 and 2.