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. 2019 Aug 21;13:390. doi: 10.3389/fncel.2019.00390

FIGURE 3.

FIGURE 3

A804598 administration prevents the BzATP-dependent increase of energy expenditure. Female C57BL/6J mice (n = 4) after adapting to the metabolic chambers for 24 h, were subjected to IC recording for 3 consecutive days according to the subsequent experimental design: day1, a single BzATP 1 mg/Kg i.p. injection and IC recording for 24 h,; day 2, a single A804598 90 mg/Kg i.p. injection and IC recording for 24 h; day 3, A804598 injection followed (after 20 min) by BzATP and IC recording for 24 h. (A) Mean (± SEM) 24 h metabolic activity is expressed as volume of oxygen consumption rate (VO2) (ml/h/kg). (B) Mean (± SEM) EE energy expenditure is expressed as Kcal/h/Kg. (∗∗P < 0,001 BzATP vs. A804598, ∗P < 0,005 BzATP vs. A804598 + BzATP).