Figure 1.

The structure of TRPV1. TRPV1 is a protein with six transmembrane regions, the fifth transmembrane protein region and the sixth transmembrane protein region of each subunit aggregate together to form a pore region for the TRPV1 channel. The amino-terminal and carboxy-terminal of TRPV1 are both intracellular.There are three anchor protein repeats and multiple phosphorylation binding sites at the N-terminus, which can bind to calmodulin and ATP. The N-terminal intracellular region contain TRP domain,calmodulin-binding sites and phosphoinositide-binding sites.