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. 2019 Aug 21;10:1885. doi: 10.3389/fimmu.2019.01885

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Copyright © 2019 Faria, Gaya da Costa, Poppelaars, Franssen, Pestana, Berger, Daha, Gaillard and Seelen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relative decrease in factor D correlates with the relative increase of soluble C5b-9 by intravenous iron in hemodialysis patients. (A) Plasma levels of factor D were determined in 32 hemodialysis (HD) patients during two consecutive dialysis sessions, one with intravenous iron (Iron), and one without (No iron). During each dialysis session, factor D levels were determined at baseline and after 4 h. Data are presented as mean and SEM. (B) The correlation between the relative change of sC5b-9 and factor D between the two HD sessions. Correlations were evaluated using the Spearman rank correlation coefficient and paired sample t-test was used to compare values before and after iron infusion. P < 0.05 were considered to be statistically significant (^**P < 0.01).