Table 1.

Physiological variables, norepinephrine dose and blood count during the experiment

Variable and time (h)	Naive	SIRS	Controls
Mean arterial pressure (mmHg)
− 24		71 (± 6)	76 (± 13)
− 22		84 (± 6)	75 (± 11)
− 18		74 (± 9)	80 (± 14)
0	78 (± 11)	74 (± 9)	85 (± 10)
1	77 (± 10)	78 (± 8)*	80 (± 5)
2	77 (± 13)	91 (± 6)*	87 (± 30)
3	69 (± 11)	92 (± 7)*	95 (± 24)
4	81 (± 11)	92 (± 8)	94 (± 19)
5	76 (± 9)	88 (± 7)	77 (± 6)
6	75 (± 9)	86 (± 7)	63 (± 9)
Norepinephrine dose (μg × kg−1 × min−1)
− 24		0 (0–0)	0 (0–0.07)
− 22		0 (0–0)	0 (0–0.07)
− 18		0 (0–0)	0.06 (0–0.07)
0	0 (0–0)	0 (0–0)	0.06 (0–0.29)
1	0.06 (0–0.13)	0 (0–0)	0.26 (0.1–0.29)*
2	0.03 (0–0.13)	0 (0–0)	0.26 (0–0.58)
3	0.19 (0–0.28)	0 (0–0)*	0.26 (0–0.58)
4	0.13 (0.06–0.51)	0 (0–0)	0.26 (0–0.58)
5	0.13 (0.06–0.26)	0 (0–0)	0.26 (0–0.58)
6	0.13 (0.06–0.14)	0 (0–0)	0.26 (0–0.58)
Cardiac index (L × min−1 × m−2)
− 24		2.7 (± 0.5)	3.2 (± 0.2)
− 22		2.9 (± 0.4)	2.6 (± 0.3)
− 18		3.0 (± 0.6)	2.6 (± 0.6)
0	2.9 (± 0.9)	3.8 (± 0.6)	3.0 (± 0.4)
1	2.2 (± 0.4)	4.3 (± 0.5)***	2.7 (± 0.4)
2	2.7 (± 1.2)	3.6 (± 0.7)***	3.5 (± 0.6)
3	2.0 (± 0.2)	3.6 (± 0.7)***	3.6 (± 1.0)
4	2.0 (± 0.5)	4.0 (± 0.7)	3.6 (± 0.7)
5	2.2 (± 0.5)	3.8 (± 0.8)	4.0 (± 0.7)
6	2.5 (± 0.2)	4.4 (± 0.7)	4.4 (± 0.9)
Arterial lactate (mmol × L−1)
− 24		1.8 (± 0.26)	1.1 (± 0.38)
− 22		1.2 (± 0.21)	0.7 (± 0.19)
− 18		0.8 (± 0.13)	0.7 (± 0.16)
0	1.2 (± 0.37)	0.8 (± 0.16)	0.8 (± 0.11)
1	2.2 (± 0.82)	1.0 (± 0.10)***	1.4 (± 1.9)
2	2.2 (± 0.27)	1.2 (± 0.21)***	1.9 (± 0.56)
3	3.0 (± 0.69)	1.1 (± 0.29)***	2.4 (± 0.32)
4	2.6 (± 1.2)	1.1 (± 0.34)	1.8 (± 0.81)
5	2.0 (± 1.2)	1.0 (± 0.27)	1.5 (± 0.76)
6	1.4 (± 1.1)	0.9 (± 0.19)	1.3 (± 0.81)

Values are expressed as mean (± SD), except the norepinephrine dose that is expressed as median (IQR)

Difference vs. the naive group 1–6 h assessed with ANOVA III for repeated measurements except for norepinephrine dose assessed with the Mann-Whitney U test

*p < 0.05

***p < 0.001