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. 2019 Aug 16;12(11):1468–1479. doi: 10.1016/j.tranon.2019.07.019

Table 2.

Frequency (%) of Tumor-Infiltrating Leukocyte Subsets in HCC and CCA BIOPSIES, Classified in Different Tumor Grades and Risk Stratification Categories

% Monocytes
Macrophages
Lymphocytes
Neutrophils
Mean ± SD Mean ± SD Mean ± SD Mean ± SD
CCA (global mean) (n = 8) 1.44 ± 1.29 2.07 ± 1.83 7.7 ± 5.6a 14.8 ± 16.7
CCA Risk stratification Low 0.40 ± 0.42 2.25 ± 2.90 8.0 ± 8.5 6.8 ± 2.5
High 1.97 ± 1.28 1.98 ± 1.65 7.5 ± 5.4 18.9 ± 20.0
Grades G1-G2 1.17 ± 1.16 2.08 ± 1.81 5.8 ± 5.5 19.8 ± 18.8
G3-G4 2.00 ± 1.84 2.05 ± 2.62 11.4 ± 5.2 4.9 ± 5.9
HCC (global mean) (n = 21) 2.56 ± 3.16 1.24 ± 1.23 33.1 ± 20.8a 7.2 ± 5.7
HCC Risk stratification Low 3.52 ± 4.16 1.36 ± 1.36 30.4 ± 21.9 5.5 ± 4.4
High 1.49 ± 0.67 1.08 ± 1.13 36.1 ± 20.7 8.9 ± 6.6
Grades G1-G2 2.75 ± 3.74 1.08 ± 1.24 28.7 ± 19.9 7.4 ± 6.6
G3-G4 2.10 ± 0.94 1.83 ± 1.22 43.6 ± 21.2 6.7 ± 3.4

Independent-samples Mann-Whitney U test and Kruskal-Wallis multiple comparison tests were performed with a significance level of .05 (P < .05). The results are given as mean ± SD. Global mean indicates mean values in CCA and HCC groups without discrimination among tumor grades or stages.

a

CCA vs. HCC.